Current Research Projects
The role of Co-chaperones in neurodegenerative diseases/Clinical and experimental stroke studies
- Methods:
- molecular biology
- Members:
- PD Dr. Jan Liman (Team Leader), Johann Christoph Becker, Dr. Imke Amanzada, Alexander Kleinknecht, Dr. Ilko Maier, Dr. Marlena Schnieder, Tariq Siddiqui
Expression of anti-apoptotic or neuroprotective gene products by viral vectors
- Methods:
- construction of viral vectors, in vivo and in vitro gene expression
- Members:
- Dr. Sebastian Kügler (Team Leader), Shi Cheng, Sonja Heyroth, Dr. Sameehan Mahajani, Maryna Psol, Dr. rer. nat. Grit Taschenberger , Dr. Yuliya Tereshchenko, Dr. rer. nat. Muzna Zahur, Monika Zebski
Translational Neurodegeneration
- Methods:
- microsurgery (axotomy, ONcrush, PN autograft, spinal cord lesion), molecular biology,nprimary cell culture (RGC, HC, MDN), siRNA applications, SOD G93A mouse model
- Members:
Mechanisms of neuronal and axonal degeneration in Multiple Sclerosis
- Methods:
- animal models of MS including in vivo electrophysiology of the visual system, immunohistochemistry, histopathology, Western blot analysis, primary cell culture, ELISA, luminex assays, CSF analysis, MRI; clinical studies in MS patients including investigator initiated double-blind phase II clinical trials, MRI and MR spectroscopy, optical coherence tomography, neuropsychological testing, electrophysiology and CSF analysis.
- Members:
- Irina Graf, Dr. Katharina Hein (Team Leader), Prateek Kumar, Henrike Menthoff, Johannes Ruhe
The role of Micro-RNAs in neurodegenerative diseases and Ischemia
- Members:
- Prof. Dr. Uwe Michel (Team Leader), Barbara Müller
The role of neuroregenerative mechanisms in cerebral ischemia
- Members:
- Thorsten Döppner, M.D., M.Sc. (Team Leader), Regine Kruse, Jalal Omrani, Khalid Tai, Bozena Zechmeister, Xuan Zheng